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| TBI6050 | Developmental Biology | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Compulsory | | Department | DEPARTMENT of MEDICAL BIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Group study | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Bayram TORAMAN | | Co-Lecturer | Prof.Dr. Ersan KALAY, ASSIST. PROF. DR. Tuba DİNÇER | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | This course aims to teach the embryonic development processes in multicellular organisms and the genetic mechanisms that control these processes. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | explain in general the mechanisms of gene expression and cell-cell communication in embryonic developmental processes. | 3 | 1 | | PO - 2 : | explain in general the steps of embryonic development in multicellular organisms. | | 1 | | PO - 3 : | understand the common aspects and differences of embryonic development in model organisms (Drosophila, sea Urchin, fishes and amphibians). | | | | PO - 4 : | comprehend embryological development steps in general in mammalian organisms (mouse, human). | | | | PO - 5 : | comprehend sexual development, organogenesis and morphogenesis in mammals. | | | | PO - 6 : | understand the genetic causes of congenital anomalies in humans. | | | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| 1. Introducing Developmental Biology
2. Important Cellular Behaviors İn Morphogenesis, Evolutionary Embryology, Medical Embryology and Teratology
3. Different Gene Expression In Developmental Processes
4. Cell-Cell Communication in Development
5. Embryonic Development in Model Organisms, Symmetry Formation and Early Development Processes
6. Organogenesis and Stem Cell Concept
7. Formation of The Central Nervous System and Epidermis From The Ectoderm
8. Neural Crest Cells and Neural Crest-Derived Structures and Organs (Mouth, Jaw and Face Formation)
9. The Endoderm and Mesoderm-Derived Organs and Structures
10. Formation of The Epithelial Tissue of The Digestive and Respiratory Organs
11. Mesoderm-Derived Muscle-Bone and Cardiovascular Tissue Formation
12. Formation of The Urogenital Tissues From Mesoderm
13. Formation of Four Limbs (Extremities) of The Tetrapods and Pattern Formation
14. Hox Genes and The Control of The Formation of Limbs, Sonic Hedgehog Pathway
15. Genetic Mechanisms of Primary Sex Determination
16. Genetic Errors of Human Embryonic Development |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introducing Developmental Biology | | | Week 2 | Important Cellular Behaviors İn Morphogenesis, Evolutionary Embryology, Medical Embryology And Teratology | | | Week 3 | Differential Gene Expression In Developmental Processes | | | Week 4 | Cell-Cell Communication in Development | | | Week 5 | Embryonic Development in Model Organisms, Symmetry Formation and Early Development Processes | | | Week 6 | Organogenesis and Stem Cell Concept | | | Week 7 | Formation Of The Central Nervous System And Epidermis From The Ectoderm | | | Week 8 | Mid-term exam | | | Week 9 | Neural Crest Cells And Neural Crest-Derived Structures And Organs (Mouth, Jaw And Face Formation)
The Endoderm and Mesoderm-Derived Organs And Structures
| | | Week 10 | Formation Of The Epithelial Tissue Of The Digestive And Respiratory Organs
Mesoderm-Derived Muscle-Bone And Cardiovascular Tissue Formation | | | Week 11 | Formation Of The Urogenital Tissues From Mesoderm | | | Week 12 | Student presentation | | | Week 13 | Formation Of Four Limbs (Extremities) Of The Tetrapods And Pattern Formation | | | Week 14 | Hox Genes And The Control Of The Formation Of Limbs, Sonic Hedgehog Pathway | | | Week 15 | Embryonic Mechanisms of Gender Determination
Genetic Errors of Human Embryonic Development | | | Week 16 | Final Exam | | | |
| 1 | Scott F Gilbert. 2014; Developmental Biology, Sunderland (MA): Sinauer Associates | | | 2 | Lewis Wolpert, Cheryll Tickle. 2010; Principles of Development, Oxford University Press. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 2 | 30 | | Presentation | 12 | | 1 | 20 | | End-of-term exam | 16 | | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 10 | 30 | | Sınıf dışı çalışma | 1 | 2 | 2 | | Laboratuar çalışması | 2 | 9 | 18 | | Arasınav | 2 | 1 | 2 | | Ödev | 2 | 5 | 10 | | Total work load | | | 62 |
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