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| TBIO618 | Protein Synthesis | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Compulsory | | Department | DEPARTMENT of MEDICAL BIOCHEMISTRY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Doç. Dr. Fulya BALABAN YÜCESAN | | Co-Lecturer | None | | Language of instruction | | | Professional practise ( internship ) | None | | | | The aim of the course: | | The course aims to provide the students with a general knowledge on DNA, RNA, protein synthesis and post-translational modifications. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Discuss about the relationship betweet the base sequence on DNA and the amino acid sequence of a protein | 1,2,3 | 1,3 | | PO - 2 : | Explain the types and the functions of RNA in protein synthesis | 1,2,3 | 1,3 | | PO - 3 : | List the stages of protein synthesis with their enzymes | 1,2,3 | 1,3 | | PO - 4 : | Discuss about the mechanisms and aims of pottranslational events | 1,2,3 | 1,3 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| The structure of DNA, DNA replication, RNA and transcription, Genetic code, The initiation of protein synthesis, Initiation factors and enzymes, Elongation factors, Termination, Post-translational modifications, Protein targeting |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Structure and chemical properties of DNA
Procaryotic and eucaryotic DNAs | | | Week 2 | Genetic roles of DNA
Procaryotic and eucaryotic DNA replication | | | Week 3 | Structure and types of RNA
Procaryotic and eucaryotic transcription mechanisms | | | Week 4 | Control of transcription and transcription factors | | | Week 5 | rRNA structure and posttranscriptional modification | | | Week 6 | tRNA structure and posttranscriptional modification and its aminoacylation
Procaryotic and eucaryotic mRNA | | | Week 7 | The properties of genetic code and the "wobble" hypothesis | | | Week 8 | Mid-term exam | | | Week 9 | Initiaton of protein synthesis
Initiation factors and procaryotic and eucaryotic differences | | | Week 10 | Initiaton of protein synthesis
Initiation factors and procaryotic and eucaryotic differences | | | Week 11 | Elongation and termination stages of protein synthesis, procaryotic and eucaryotic factors
| | | Week 12 | protein folding | | | Week 13 | Posttranslational modifications | | | Week 14 | Protein targeting
Protein turover and degradation | | | Week 16 | End-of-term exam | | | |
| 1 | Nelson, D.L., Cox, M.M., 2005, Lehninger Principles of Biochemistry, W.H. Freeman and Company. | | | 2 | Küfrevioğlu, Ö. İ., Keha, E. E., 2009, Biyokimya, Aktif Yaınevi.6.baskı | | | |
| 1 | Berg, J.M., Tymoczko, J.L., Stryer, L. 2002, Biochemistry, W.H. Freeman and Company | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 2 | 30 | | Homework/Assignment/Term-paper | 11 | | 3 | 20 | | End-of-term exam | 16 | | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 5 | 14 | 70 | | Arasınav için hazırlık | 4 | 7 | 28 | | Arasınav | 3 | 1 | 3 | | Ödev | 3 | 13 | 39 | | Dönem sonu sınavı için hazırlık | 3 | 14 | 42 | | Dönem sonu sınavı | 3 | 1 | 3 | | Total work load | | | 227 |
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