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| EBK5217 | Biochemistry of Drug Metabolism | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of BIOCHEMISTRY (PHARMACY) | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Practical | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Doç. Dr. İnci Selin DOĞAN | | Co-Lecturer | - | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Selective chemotherapeutic control of the biological processes involved in important biological catalysts are taught and effector mechanisms of action. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | the mechanism of action of the drug development | 1 - 4 | | | PO - 2 : | New pathways to improve drug activity | 4 - 8 | | | PO - 3 : | Develop methods to reduce drug toxicity | 4 - 8 | | | PO - 4 : | Develop methods for working with biological systems | 4 - 8 | | | PO - 5 : | Chemical investigation of the mechanisms of action of enzymes and coenzymes | 4 - 8 | | | PO - 6 : | Synthesis and design of receptor-targeted active region | 4 - 8 | | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Drug absorption, distribution, metabolism, excretion and toxicity comprising chemical factors examined |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | terminology and ADME | | | Week 2 | preclinical works | | | Week 3 | metabolism reactions-faz I oxidation | | | Week 4 | metabolism reactions-faz I oxidation | | | Week 5 | metabolism reactions-faz I reduction | | | Week 6 | metabolizma reaksiyonları - faz I hydrolisis | | | Week 7 | metabolizma reaksiyonları - faz II conjugation | | | Week 8 | mid term exam | | | Week 9 | absorbtion of drugs | | | Week 10 | dissintegration of drugs | | | Week 11 | drug excretion | | | Week 12 | drug toxicity | | | Week 13 | sample metabolism studies | | | Week 14 | sample metabolism studies | | | Week 15 | receptor interaction | | | Week 16 | final examination | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | 12.04.2022 | 1 | 50 | | Presentation | 12 | 12.05.2022 | 1 | 10 | | Homework/Assignment/Term-paper | 12 | 12.05.2022 | 1 | 10 | | End-of-term exam | 16 | 12.06.2022 | 1 | 15 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | | | | |
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