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| BIY4044 | Antioxidants and Human Nutrition | 3+0+0 | ECTS:5 | | Year / Semester | Spring Semester | | Level of Course | First Cycle | | Status | Elective | | Department | DEPARTMENT of BIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Doç. Dr. Nesrin ÇOLAK | | Co-Lecturer | Prof. Dr. Faik Ahmet AYAZ | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The aim of this course is to provide students with knowledge and skills on the definition and sources of free radicals, examination of the physiopathological effects of radicals, antioxidants, antioxidant sources, the place of antioxidants in nutrition, and the effect of antioxidants on free radicals. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | be able to define antioxidants and classify antioxidants. | 1 - 2 - 3 - 4 - 5 | 1, | | LO - 2 : | know the mechanisms of action of antioxidants | 1 | 1, | | LO - 3 : | be able to define free radicals, have information about their types, sources, and effects. | 1 | 1, | | LO - 4 : | know the place and importance of antioxidants in nutrition. | 1 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Cell and organelles, Secondary metabolites, Phenolic compounds, Flavonoids, Anthocyanins, Phenolic acids, Non-enzymatic antioxidants other than phenolic compounds, Thiol compounds, Enzymatic antioxidants, Oxidative stress, Major plants containing antioxidants, Effect of antioxidants on organ damage, Meeting daily antioxidant needs, Antioxidant nutrition in pregnancy and old age |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction to the cell
Cell, membrane structure, membrane transitions, organelles and their functions
| | | Week 2 | Secondary metabolites
Secondary metabolite precursor compounds
Classification of secondary metabolites
Synthesis pathways of secondary metabolites
Secondary metabolite-cell organelle relationship
| | | Week 3 | Phenolic Compounds
Classification of Phenolic Compounds
Synthetic Pathway of Phenolic Compounds
Antioxidant Properties of Phenolic Compounds
Polyphenols
Catechins
Role in Human Health
| | | Week 4 | Flavonoids
Classification of flavonoids
Synthetic pathways and chemical structure of flavonoids
Antioxidant properties of flavonoids
Role in Human Health
| | | Week 5 | Anthocyanins
Classification of anthocyanins
Synthetic pathways and chemical structure of anthocyanins
Anthocyanins' antioxidant properties
Role in Human Health
| | | Week 6 | Phenolic Acids
Classification and chemical structure of phenolic acids
Antioxidant properties of phenolic acids
Role in Human Health
| | | Week 7 | Non-enzymatic antioxidants other than Phenolic Compounds
Ascorbic acid
Tocopherol
Carotenoids
Melatonin
Role in Human Health
| | | Week 8 | Thiol Compounds
Cysteine
Glutathione
N-acetylcysteine
Methionine
Lipoic acid
Roles in Human Health
| | | Week 9 | Middle Exam | | | Week 10 | Enzymatic antioxidants
Competitive and non-competitive inhibition
Superoxide Dismutase
Glutathione Peroxidase
Glutathione S-Transferase
Catalase
Mitochondrial Cytochrome Oxidase
| | | Week 11 | Oxidative Stress
Oxidative Damage in Biopolymers
Classification of Free Radicals
Reactive Oxygen Species
Reactive Nitrogen Species
Interactions of Free Radicals with Cellular Structures
Role of Antioxidants in Preventing Oxidative Stress
| | | Week 12 | Major Plants Containing Antioxidants
Vegetables Containing Antioxidants
Fruits Containing Antioxidants
Snacks Containing Antioxidants
The Importance of Natural Antioxidants
Proper Consumption of Antioxidant Containing Foods
| | | Week 13 | Effects of Antioxidants on Organ Damage
Antioxidant-Disease Relationship (Cancer, Metabolic Disorders,
Benefits for Hair, Bone and Skin
Effects on Cholesterol
Effects on Allergy and Inflammation
| | | Week 14 | Meeting Daily Antioxidant Needs
Absorption of Antioxidants
Antioxidant Deficiency and Excess
| | | Week 15 | Antioxidant Nutrition in Pregnancy
Aging Delaying Effects
Antioxidant Nutrition in Immune Protection
| | | Week 16 | Exam week | | | |
| 1 | Ramazan Mammadov, Serbest Radikaller ve Antioksidanlar, 2020. | | | |
| 1 | Doç. Dr. Gökçen YILDIZ & Doç. Dr. Gülçin YILDIZ, Antioksidanlar ve Fenolik Maddeler, İksad Pblishing House, 2022 | | | 2 | Doç. Dr. İbrahim AKTAŞ, Antioksidan İçeren Besinler, İksad Pblishing House, 2023 | | | 3 | Doç. Dr. Sedat BİLGİÇ, Dr. Öğr. Üyesi İbrahim AKTAŞ, Antioksidan İçeren Besinler, İksad Pblishing House, 2021 | | | 4 | Serdal ÖĞÜT, Doğal Antioksidanların Önemi, Journal of Adnan Menderes University Agricultural Faculty 2014; 11(1) : 25 - 30 | | | 5 | Prof. Dr. Erdinç DEVRİM, SERBEST RADİKALLER ve ANTİOKSİDAN SAVUNMA MEKANİZMALARI, Ankara Üniversitesi Tıp Fakültesi
Tıbbi Biyokimya AD | | | 6 | Prof. Dr. Abdurrahman AKTÜMSEK, Prof. Dr. Gökalp ÖZMEN GÜLER, Doç. Dr. Yavuz Selim ÇAKMAK, Doç .Dr. Gökhan ZENGİN, Öğr. Gör. Şengül UYSAL, Beslenme İlkeleri, Nobel Yayın Evi, 2020. | | | 7 | Prof. Dr. Aliye ÖZENOĞLU, Temel Beslenme İlkeleri ve Laboratuvar Uygulamaları, Eğitim Yayınevi, 2023 | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 18.04.2026 | | 50 | | End-of-term exam | 16 | 06.06.2026 | | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 3 | 14 | 42 | | Arasınav için hazırlık | 4 | 6 | 24 | | Arasınav | 1 | 1 | 1 | | Ödev | 4 | 4 | 16 | | Dönem sonu sınavı için hazırlık | 4 | 6 | 24 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 150 |
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