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| MBGL5045 | Regulation of Prokaryotic and Eukaryotic Gene Expressions | 3+0+0 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of MOLECULAR BIOLOGY and GENETICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Prof. Dr. Kadriye İNAN BEKTAŞ | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Understanding the regulation of mechanisms related to central dogma according to compartments in the cell, Understanding the role of transcriptional differences in cell specialization, Understanding the role of gene expression in cellular and organism behaviors. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Understands the differences of different organisms in gene regulation control mechanisms | 1,5 | 1, | | PO - 2 : | Understand the properties of the genome of intracellular organelles | 1,5 | | | PO - 3 : | Understand the properties, genetic and epigenetic regulations of the human genome | 1,5 | 1, | | PO - 4 : | Learn about gene expression disorders and medical applications | 1,5 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| In this course, understanding of regulation of gene expression in prokaryotes and eukaryotes, analysis of organelle and viral genome gene expressions, recombination in genetic regulation, role of nuclear matrix in transcription, cancer formation as a result of disruption of gene regulation, medical control of gene transcription. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Prokaryotic transcriptional regulation | | | Week 2 | Eukaryotic transcriptional regulation | | | Week 3 | Viral gene expression and regulation | | | Week 4 | Organelle genomes | | | Week 5 | Gene recombination and expression in B cells | | | Week 6 | Gene recombination and expression in T cells | | | Week 7 | Organization of the human genome | | | Week 8 | Organization of the human genome | | | Week 9 | Mid term exam | | | Week 10 | Nuclear matrix, chromosome habitat and transcriptional factor | | | Week 11 | Gene expression dynamics | | | Week 12 | Global gene transcription pattern | | | Week 13 | Cancer | | | Week 14 | Genetic control of behavior | | | Week 15 | Medical practices that intensify in transcriptional control mechanism | | | Week 16 | End of term exam | | | |
| 1 | MOLECULAR BIOLOGY, ROBERT WEAVER, MCGRAWHIL EDUCATION, 5TH EDITION, ISBN 978-0073525327, 2011 | | | 2 | MOLECULAR BIOLOGY OF THE CELL, BRUCE ALBERTS, ALEXANDER JOHNSON, JULIAN LEWIS, MARTIN RAFF, KEITH ROBERTS VE PETER WALTER, GARLAND SCIENCE, 5TH | | | |
| 1 | MOLECULAR BIOLOGY OF THE GENE, JAMES WATSON, TANIA BAKER, STEPHEN BELL, ALEXANDER GANN, MICHAEL LEVINE VE RICHARD LOSICK, COLD SPRING HARBOR LABORATORY PRESS, 6TH EDITION, ISBN 978-0-321-50781-5, 2008 | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | | 1 | 30 | | Presentation | 13
14 | | | 20 | | End-of-term exam | 16 | | | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 4 | 10 | 40 | | Arasınav için hazırlık | 3 | 8 | 24 | | Arasınav | 2 | 1 | 2 | | Dönem sonu sınavı için hazırlık | 3 | 14 | 42 | | Dönem sonu sınavı | 2 | 1 | 2 | | Diğer 1 | 4 | 10 | 40 | | Total work load | | | 192 |
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