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| BIYL5230 | Gene Regulation | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of BIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Prof. Dr. Ali Osman BELDÜZ | | Co-Lecturer | None | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The course aims to prepare students to advanced research by teaching the classical and novel gen transfer methods, and the regulation of expression of eukaryotic genes on the basis of previous and recent studies |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | integrate the various mechanisms that nature uses to regulate gene expression | 2,3,5,8 | 1,3,6, | | PO - 2 : | identify and distinguish temporal and special gene expression | 2,3,5,8 | 1,2, | | PO - 3 : | understand how transcription factors, promoters and enhancers can specify gene regulation | 2,3,5,8 | 1,2, | | PO - 4 : | explain the development of an organ | 2,3,5,8 | 1, | | PO - 5 : | explain the various events that determine and control gene expression in eukaryotes | 2,3,5,8 | 1,5, | | PO - 6 : | understand the complexity of gene expression in eukaryotes | 2,3,5,8 | 1,3,5, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Eukaryotic control elements. Vectors. Processing of proteins encoded by transferred genes. Gene trasfer methods. Assays for gene transfer and expression. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Tissue specific expression of proteins and messenger RNAs | | | Week 2 | The DNA of Different Cell Types is Similar in Both Amount and Type | | | Week 3 | Gen expression: levels of expression, transkription | | | Week 4 | Gen expression: levels of expression, post transkriptional events | | | Week 5 | Regulation at transkription | | | Week 6 | Posttranskriptional refulations:RNA splicing, RNA editing, RNA stability | | | Week 7 | Posttranskriptional refulations:translation, regulation of translation by small RNAs | | | Week 8 | transcriptional regulation: chromatin structure | | | Week 9 | Mid-term exam | | | Week 10 | transcriptional regulation: DNA sequence elements | | | Week 11 | transcriptional regulation: DNA binding by transcription factors | | | Week 12 | transcriptional regulation: what regulates regulators | | | Week 13 | gene regulation and human diseases | | | Week 14 | transkription factors as oncogenes, homework and project presentations | | | Week 15 | transkription factors as anti oncogenes, homework and project presentations | | | Week 16 | End-of-term exam | | | |
| 1 | Gene Regulation: A Eukaryotic Perspective, 2008, D.S. Latchman, 288, Springer; 2nd edition,Paperback, ISBN-13: 978-0412602009 | | | |
| 1 | Regulation of Gene Expression, 2006,Gary H. Perdew, Jack P. Vanden Heuvel, Jeffrey M. Peters, Hardcover: 344 pp, Humana Press; 1 ed. SBN-13: 978-1588292650 | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 12/4/2024 | 1,5 | 30 | | Presentation | 15 | 07/05/2024 | 1 | 10 | | Homework/Assignment/Term-paper | 15 | 07/125/2024 | 1 | 10 | | End-of-term exam | 16 | 06/06/2024 | 1,5 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 5 | 14 | 70 | | Laboratuar çalışması | 0 | 0 | 0 | | Arasınav için hazırlık | 6 | 7 | 42 | | Arasınav | 2 | 1 | 2 | | Uygulama | 0 | 0 | 0 | | Klinik Uygulama | 0 | 0 | 0 | | Ödev | 18 | 1 | 18 | | Proje | 0 | 1 | 0 | | Kısa sınav | 1 | 7 | 7 | | Dönem sonu sınavı için hazırlık | 6 | 7 | 42 | | Dönem sonu sınavı | 2 | 1 | 2 | | Diğer 1 | 0 | 0 | 0 | | Diğer 2 | 0 | 0 | 0 | | Total work load | | | 225 |
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